• As an undergrad at the University of Richmond, a liberal arts college a lot like 澳门金沙线上赌博官网, 我恍然大悟!” moment when I took biochemistry: I wanted to ask biology questions through the lens of chemistry.  I carried out undergraduate research in Michelle Hamm’s lab, where we studied the replication of oxidatively damaged DNA.  在里士满, I worked for two years as a technician and lab manager in Joel Meyer’s toxicology lab at Duke University, studying the impacts of environmental mutagenesis on mitochondrial DNA.  During my time at Duke, I discovered a passion for teaching and training undergraduate students in the lab, which led me to a graduate program at Cornell University.  在那里, I shifted gears to the study of Golgi membrane trafficking in Chris Fromme’s lab, where I learned to tackle complex problems with an array of approaches,包括 protein biochemistry, cell and molecular biology, and structural biology.  I then returned to mtDNA questions during my postdoc in Bill Copeland’s lab at the National Institute of Environmental Health Sciences, before coming to 澳门金沙线上赌博官网 in 2023 with my own plans for an exciting research program focused on the regulatory mechanisms of mtDNA replication.  I am passionate about teaching and mentoring, as well as training students in the lab.  I value the curious and expansive mindset cultivated by a liberal arts education, and I look forward to helping 澳门金沙线上赌博官网 students find their passions and grow into lifelong learners and leaders.

    • Postdoc in 生物化学, The National Institute of Environmental Health Sciences
    • Ph.D. in 生物化学, Molecular and Cell Biology, Cornell University
    • B.S. in 生物化学 and B.A. in Latin American and Iberian Studies, University of Richmond
    • Gustafson马*, 佩雷拉L *, Shi M, and 科普兰WC. “Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces.” DNA修复. 2021 Aug;107:103212. doi: 10.1016/j.dnarep.2021.103212
    • Gustafson马*, Sullivan ED*, and 科普兰WC. “Consequences of compromised mitochondrial genome integrity.” DNA修复. 2020 Sep;93:102916. doi: 10.1016/j.dnarep.2020.102916
    • Gustafson马*, 麦考密克EM *, 佩雷拉L *, 龙利乔丹, 白R, 香港J, Dulik米, 沈L, 戈尔茨坦交流, 麦科马克SE, Laskin提单, 勒罗伊英国石油公司, Ortiz-Gonzalez XR, 艾灵顿毫克, 科普兰WC, 和福克MJ. “Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes.” 《澳门金沙线上赌博官网》. 2019 Sep 3;14(9):e0221829. doi: 10.1371 /杂志.玉米饼.0221829
    • Gustafson马 and Fromme JC. “Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments.” Mol生物细胞. 2017 Dec 1;28(25):3660-3671. doi: 10.1091 / mbc.E17-06-0370
    • Kasiviswanathan R*, Gustafson马*, 科普兰WC, and Meyer JN. “Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers.” 生物化学. 2012 Mar 16;287(12):9222-9. doi: 10.1074 / jbc.M111.306852
    • 哈姆毫升, 克劳利KA, Ghio米, Del Giorno L, Gustafson马, Kindler柯, 利贡连续波, Lindell马, 麦克费登EJ, Siekavizza-Robles C, 萨默斯先生. “Importance of the C2, N7, and C8 positions to the mutagenic potential of 8-Oxo-2'-deoxyguanosine with two A family polymerases.” 生物化学. 2011 Dec 13;50(49):10713-23. doi: 10.1021 / bi201383c
       
    • Mitochondrial DNA Replication
    • Protein 生物化学
    • Cell and Molecular Biology
    • 酵母遗传学
    • Structural Biology

    The Gustafson Lab is focused on understanding the molecular decision-making involved in high fidelity mitochondrial DNA replication in the fission yeast model Schizosaccharomyces pombe.  We use approaches in protein biochemistry, cell and molecular biology, 遗传学, 显微镜, and structural biology to identify and characterize molecular- and atomic-level interactions that help maintain mtDNA integrity.
     

    • 生物化学我

    • 生物化学实验室

    • NIEHS 2021 Group Merit Award: For the seamless and effective conversion of outreach and research training activities to a virtual platform during the COVID-19 pandemic
    • Harry and Samuel Mann Outstanding Graduate Student Award 2016
    • 乔治P. Hess Travel Award 2015
    • Rita and Joe Calvo Graduate Student Teaching Award 2013